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來凱醫藥-B(02105.HK)afuresertib聯合治療臨床試驗結果表明可降低疾病進展
阿思達克 01-29 08:57
來凱醫藥-B(02105.HK)公布afuresertib聯合紫杉醇在美國和中國治療鉑耐藥卵巢癌(PROC)患者的國際多中心註冊二期臨床試驗(PROFECTA -II)頂線數據。 有關研究評估afuresertib聯合紫杉醇治療與單獨紫杉醇對照對鉑耐藥卵巢癌(PROC)女性患者的療效和安全性。該研究在美國和中國隨機入組了150名患者到試驗組和對照組。主要終點為研究者評估的無進展生存期。次要終點包括總生存期、客觀緩解率和持續緩解時間。 試驗結果表明,afuresertib聯合紫杉醇週療可以降低疾病進展或死亡的風險(無進展生存期,PFS),但試驗沒有達到統計學意義。公司計劃與監管機構就該試驗結果討論決定下一步的註冊臨床路徑。詳細的試驗數據將在醫學會議上公布。
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