騰盛博藥(02137.HK):新冠肺炎療法之試驗三期研究獲得積極數據
騰盛博藥-B(02137.HK)公布,在ACTIV-2試驗的中期分析中,公司的SARS-CoV-2(引起COVID-19的病毒)中和單克隆抗體BRII-196/BRII-198聯合療法(「BRII-196/BRII-198聯合療法」)在837例疾病進展高風險的新冠肺炎(COVID-19)門診患者中,與安慰劑相比,住院及死亡的複合終點降低78%,具有統計學顯著性,相對危險度(RR):0.22(95%置信區間:0.05,0.86)P值<.00001(未調整,單側檢驗)。
在基於837名受試者部分隨訪的中期分析中,觀察到住院(治療組12例及安慰劑組45例)及死亡(治療組1例及安慰劑組9例)人數均有下降。其他亞組分析可能進一步描述在症狀出現後較早期(首發症狀後5天內)使用BRII-196/BRII-198治療相比更晚的(首發症狀後6-10天)使用帶來的臨床獲益,為制定真實世界治療決策提供獨到的見解。
針對內地近期出現的由德爾塔變異株等引起的COVID-19病例,騰盛博藥已與內地政府機構及醫院開展合作,向廣州、深圳、瑞麗、昆明、南京、揚州、張家界以及鄭州提供BRII-196/BRII-198開展臨床救治。
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