樂普生物-B(02157.HK)治療鼻咽癌藥物獲美國授予快速通道資格
樂普生物-B(02157.HK)公布,候選藥物MRG003近期已獲美國食品藥監局授予快速通道資格(FTD),用於治療復發性或轉移性鼻咽癌(R/M NPC)。
MRG003是一種由EGFR靶向單克隆抗體與強效的微管抑制有效載荷一甲基澳瑞他汀E分子通過纈氨酸-瓜氨酸鏈接體偶聯而成的ADC。其以高親和力特異性地結合腫瘤細胞表面的EGFR,通過內吞及溶(酉每)體蛋白(酉每)裂解後釋放強效的有效載荷,從而導致腫瘤細胞死亡。
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