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聖諾醫藥(02257.HK)治療皮膚癌藥物具良好可行性
阿思達克 08-29 08:35
聖諾醫藥-B(02257.HK)公布,其核心候選產品STP705在治療皮膚基底細胞癌(BCC)的II期臨床試驗中,接受180μg劑量給藥的隊列實現100%完全清除(CR),表明該療法具有良好的可行性。STP705是一種siRNA(小干擾核酸)療法,是由兩個siRNA寡核(甘)酸組成的TGF-β1/COX-2雙靶點抑制劑。 公司指出,除實現100%的完全清除(CR)外,隊列中5名受試者還顯示出穩定的或更優的美容效果,具有良好的安全性(無不良事件)且沒有明顯的皮膚不良反應。公司目前正在繼續進行劑量爬坡試驗以展開劑量研究,預計2023年第一季獲得最終報告。
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