歌禮制藥-B(01672.HK):第二款FASN抑制劑ASC60治療晚期實體瘤臨試申請獲國家藥監局受理
格隆匯1月26日丨歌禮制藥-B(01672.HK)發佈公吿,經與國家藥監局溝通交流,歌禮第二款脂肪酸合成酶(FASN) 抑制劑ASC60治療晚期實體瘤的臨牀試驗(IND)申請已獲中國國家藥監局受理。ASC60進一步加強了歌禮的腫瘤管線。
根據披露,許多實體瘤和血液腫瘤中均發現脂肪酸合成酶的過度表達,包括非小細胞肺癌、乳腺癌、卵巢癌、前列腺癌、結腸癌、胰腺癌、複發性膠質母細胞瘤和非霍奇金淋巴瘤。ASC60(國外代號為TVB-3567)是一種非常強效的口服脂肪酸合成酶抑制劑,脂肪酸合成酶是調節脂肪酸從頭合成(DNL)途徑中的關鍵酶。ASC60通過阻斷脂肪酸從頭合成,抑制腫瘤細胞能量供應和擾亂腫瘤細胞膜磷脂組成。根據包括動物模型療效在內的臨牀前數據,預測ASC60人體有效劑量將在10mg/m2–20mg/m2之間。
Follow us
Find us on
Facebook,
Twitter ,
Instagram, and
YouTube or frequent updates on all things investing.Have a financial topic you would like to discuss? Head over to the
uSMART Community to share your thoughts and insights about the market! Click the picture below to download and explore uSMART app!

Disclaimers
uSmart Securities Limited (“uSmart”) is based on its internal research and public third party information in preparation of this article. Although uSmart uses its best endeavours to ensure the content of this article is accurate, uSmart does not guarantee the accuracy, timeliness or completeness of the information of this article and is not responsible for any views/opinions/comments in this article. Opinions, forecasts and estimations reflect uSmart’s assessment as of the date of this article and are subject to change. uSmart has no obligation to notify you or anyone of any such changes. You must make independent analysis and judgment on any matters involved in this article. uSmart and any directors, officers, employees or agents of uSmart will not be liable for any loss or damage suffered by any person in reliance on any representation or omission in the content of this article. The content of the article is for reference only and does not constitute any offer, solicitation, recommendation, opinion or guarantee of any securities, virtual assets, financial products or instruments. Regulatory authorities may restrict the trading of virtual asset-related ETFs to only investors who meet specified requirements. Any calculations or images in the article are for illustrative purposes only.
Investment involves risks and the value and income from securities may rise or fall. Past performance is not indicative of future performance. Please carefully consider your personal risk tolerance, and consult independent professional advice if necessary.