百济神州(06160.HK)启动一项针对在研抑制剂之1期临床试验
百济神州(06160.HK)公布,一项针对其在研造血干细胞激(酉每)1(HPK1)抑制剂BGB-15025的1期临床试验已完成首例患者给药。HPK1是T细胞受体(TCR)信号通路下游的一种激(酉每),被认为在启动T细胞的过程中起到关键作用。BGB-15025被设计旨在成为一款高强度、高选择性的HPK1小分子口服抑制剂。
这项人体首次1期临床试验(NCT04649385)旨在评估BGB-15025作为单药或联合百泽安在晚期实体瘤患者中的安全性、耐受性、药物代谢动力学状况和初步抗肿瘤活性。该试验将在全球多个国家进行。
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