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百济神州(06160.HK)与SpringWorks共同成立MapKure专注开发肿瘤生长抑制剂
阿思达克 06-21 07:32

百济神州(06160.HK)与SpringWorks Therapeutics宣布成立MapKure, LLC,由双方共同拥有。

MapKure的创立旨在开发BGB-3245,一款针对特定单聚体和二聚体B-RAF启动突变型的在研口服高选择性小分子抑制剂。

BGB-3245抑制的B-RAF突变-包括B-RAF V600突变型,B-RAF非V600突变型和RAF融合-这些突变在包括非小细胞肺癌(NSCLC)、结直肠癌(CRC)、甲状腺癌及脑肿瘤的多项实体瘤中被认定为肿瘤的生长提供了动力。

BGB-3245由百济神州科学家自主研发,目前处於临床前开发阶段。根据合作条款,SpringWorks已对MapKure进行股权投资;百济神州则贡献了在亚洲以外国家和地区(包括日本)开发及商业化BGB-3245的独家版税和里程碑授权,以换取MapKure的多数拥有权。

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